The museum is located in the building of the former Magdeburg Barracks, which served as the headquarters of the so-called Jewish Self-Government during the ghetto era. Today, this building houses extensive exhibitions presenting to the public the unique artistic, musical, literary and theatrical works of the ghetto inhabitants.

This part of the Terezín fortress system from the end of the 18th century served as a prison already in the times of the Habsburg monarchy. Among the prisoners at that time was, for example, Gavrilo Princip, the main executor of the assassination of the heir to the throne, F.F. d'Este, in Sarajevo in 1914.

In the building of the former municipal weighing scale there is a permanent exhibition dedicated to the deportations of Jews to Terezín and the deportations from the Terezín ghetto to the labour camps and especially to the extermination camps. The exhibition is not open all the time and can only be visited by appointment.

The permanent exhibition of the museum is not currently accessible, it is in the preparation phase. Visitors can, however, see the exhibition Houses Tell - the Architecture of Litoměřice, view the interiors of the old town hall or browse through an exhibition on its history and reconstruction in the arcade and courtyard of the museum.

During World War II, this building was a home for Jewish boys (10-15 years old). Nowadays there is a museum with an exhibition about the history of the ghetto and the persecution of Jews in the Protectorate of Bohemia and Moravia. Part of the exhibition is dedicated to the youngest victims of the ghetto.

The North Bohemian Art Gallery in Litoměřice manages and makes accessible collections of Czech art. It focuses on the period from the 14th century to the present day and on insite art. The collections are professionally processed, preserved and presented in its own exhibitions. The exhibition programme is held in three buildings in Litoměřice.